wow, i didn't realise MDMA affected your serotonin! well done. anyone who has ever taken MDMA knows that it blows all your serotonin. that's why 'comedowns' exist. nobody gets twitchy or irritable without a bong-hit or an MDMA dose. what are you talking about?
we're back to my discussion of the j-curve. yes, MDMA acts on your seratonin. it also helps in curing depression, PTSD, and a host of other seratonin-related mental health issues. whodathunkit?
https://hub.jhu.edu/2019/04/04/mdma-ope … -behavior/john hopkins school of medicine researchers find MDMA, or ecstasy, reactivates a learning period for social rewards, allowing test subjects to form positive associations where none existed before.
https://maps.org/research/mdmaThe FDA has designated MDMA-assisted psychotherapy for PTSD a Breakthrough Therapy, and has come to agreement with MAPS on Phase 3 protocol designs after a rigorous Special Protocol Assessment (SPA) process. MAPS' goal is to develop MDMA-assisted psychotherapy for PTSD into an FDA-approved prescription treatment by the end of 2021.
We are studying whether MDMA-assisted psychotherapy can help heal the psychological and emotional damage caused by sexual assault, war, violent crime, and other traumas. We also sponsored completed studies of MDMA-assisted psychotherapy for autistic adults with social anxiety, and MDMA-assisted psychotherapy for anxiety related to life-threatening illnesses.
In MDMA-assisted psychotherapy, MDMA is only administered a few times, unlike most medications for mental illnesses which are often taken daily for years, and sometimes forever.
https://www.newsweek.com/mice-mdma-brain-ptsd-1384948Researchers have found that the psychedelic drug MDMA reawakens a critical period in brain development in mice—a finding that casts new light on why the substance may be helpful in treating some people with post-traumatic stress disorder (PTSD).
According to a study published in the journal Nature, just a single dose of MDMA helps to re-open this critical period—think of it as a kind of window—in adult mice. During the window, the brain is more sensitive to environmental stimuli and social interaction is more rewarding.
"We think that what MDMA does is cause oxytocin to be released," Dölen told Newsweek. "That extra oxytocin in turn causes the critical period for social reward learning to come back in adults."
The researchers say that their new findings could potentially have implications for the development of treatments for certain mental health conditions in humans.
i love how you'll sensationalise the after-effects of MDMA but then don't think about ... hangovers ... you know ... that state of being literally poisoned ... by a toxic substance ... your liver full of acetaldehyde, a poison ... vomiting, dizziness, issues with blood pressure, extreme swings of mood, depression, withdrawal syndrome ....
you are literally a demonstration of my whole thesis that drinking culture is casualised and forgiven everything. i will take a comedown after a dose of MDMA over an alcohol hangover, any day of the week. i'm sure you have a great grasp on neuroscience, though.
Alcohol is one of the most widely used psychoactive substances in the world. Alcohol-induced changes in brain functions can lead to disordered cognitive functioning, disrupted emotions and behavioral changes. Moreover, these brain changes are important contributing factors to the development of alcohol use disorders, including acute intoxication, long-term misuse and dependence. According to a survey sponsored by the World Health Organization, approximately 50% of the world adult population drank alcohol in 2004 and 76 million individuals met criteria for one or more of the 60 different alcohol-related mental or behavioral disorders listed in the 10th Revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10).[1] A report on the relative contribution of different conditions to the ‘global burden of disease’ (which considers both premature mortality and disability) found that in 2010 alcohol ranked third out of the 25 major causes of the global burden of disease. In high-income countries the relative importance of alcohol-related health problems compared to other health problems is usually greater than in low- and middle-income countries.[2] Alcohol dependence, one of the most important alcohol-related conditions, is widely recognized as a growing global problem with serious medical, economic and social consequences..
Ethanol is a liposoluble neurotropic substance which penetrates the blood-brain barrier and inhibits central nervous system (CNS) functions; it is directly toxic to the brain. The etiology and pathology of alcohol dependence is the outcome of a complex interplay of biological, psychological and socio-environmental factors. CNS neurotransmitters play an important role in the development of alcohol addiction. Previous studies identified a wide range of neurotransmitters related to alcohol metabolism including dopamine, 5-HT, γ-aminobutyric acid, glutamate, endogenous opioid transmitter, acetylcholine and norepinephrine.[3] This review summarizes research progress in understanding the relationships linking the dopaminergic system and alcohol consumption.
look! we can play the 'scary scientific findings' game all day. do you really think consuming alcohol doesn't effect your brain chemistry on a long-term basis? both MDMA and your beloved alcohol are neurotoxic, d i p s h i t ! let me know when there are 60 different LSD or MDMA-related disorders!
Last edited by uziq (2019-07-17 03:15:55)